HUBUNGAN ANTARA KADAR ENZIM GAMMA GLUTAMIL TRANSFERASE DENGAN KADAR GLUKOSA DARAH PUASA PADA PASIEN DM TIPE 2 DI LABOTARORIUM PRODIA CIBUBUR JAWA BARAT

Martua, Lasroha Sumiati (2022) HUBUNGAN ANTARA KADAR ENZIM GAMMA GLUTAMIL TRANSFERASE DENGAN KADAR GLUKOSA DARAH PUASA PADA PASIEN DM TIPE 2 DI LABOTARORIUM PRODIA CIBUBUR JAWA BARAT. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Diabetes mellitus (DM) is a chronic disease that occurs due to the pancreas not being able to produce enough insulin or when the body cannot effectively use insulin, this will lead to an increase in glucose concentration or hyperglycemia accompanied by impaired metabolism of carbohydrates, fats and proteins. Fasting glucose examination parameters play a role in seeing the risk of hyperglycemia supported by Gamma GT examination, where the Gamma GT enzyme plays a role and is responsible for glutathione catabolism. Vascular injury in diabetes resulting from hyperglycemia has been linked to oxidative stress causing intracellular glutathione depletion with increased plasma ecstasy dismutase superoxide. From several studies obtained an association of increased activity of the enzyme GGT in individuals experiencing metabolic syndrome disease, as well as oxidative stress conditions. The purpose of this study is to find out Correlation between gamma glutamil transferase levels and fasting blood glucose levels in type 2 DM patients in the laboratory Prodia Cibubur West Java. Research based on data from people with diabetes mellitus who checked fasting glucose levels and Gamma GT in Prodia Cibubur for the period March 22 to April 22, 2022. The subjects of 60 patients were taken from observation data at the Prodia Cibubur Clinical Laboratory. The results showed as many as 36 men (60%) and 24 women (40%). There is a grouping of <45 years of age as many as 10 (17%) patients and ≥45 years old as many as 50 (83%) patients. In male patients type 2 diabetes mellitus has high Gamma GT levels (Gamma GT levels >66 U / L) as much as 12 (20%) patients and in female patients type 2 diabetes mellitus has high Gamma GT levels (Gamma GT levels >39 U / L) as many as 19 (31.7%) patients. Pearson correlation test results to see the correlation of fasting glucose levels with Gamma GT levels that with a confidence level of 95% obtained there is no relationship between fasting glucose levels and Gamma GT levels with values p = 0.228 and r = -0.158

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