UJI EFEK KOMBINASI EKSTRAK AIR DAUN SALAM (Syzygium polyanthum (Wight.) Walp) DAN EKSTRAK ETANOL HERBA SELEDRI (Apium graviolens L.) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI POTASSIUM OXONATE

Ristiana, Puji Astuti (2018) UJI EFEK KOMBINASI EKSTRAK AIR DAUN SALAM (Syzygium polyanthum (Wight.) Walp) DAN EKSTRAK ETANOL HERBA SELEDRI (Apium graviolens L.) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI POTASSIUM OXONATE. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Urid acid is one of non-communicable diseases who became a public health problem the world with prevalence increasing every year. Uric acid disease in Indonesia based on Basic Health Research in 2013 amounted to 11.9% based on health workers (nakes) and based on the diagnosis or symptoms of 24.7%. The prevalence of joint disease in Central Java in 2013 is 11.2% based on health diagnosis and 25.5% based on diagnosis or symptoms. Bay leaf and celery herbs are known to contain flavonoids. Flavonoids act as inhibitors of xanthine oxidase enzyme which will lead to decreased uric acid production. The research is an experimental study design with a pre and post test randomized controlled group design. There are 8 groups, namely : normal (Aquadest)l, negative (CMC-Na), positive (allopurinol), bay (SA), celery (SE), SASE 75:25, SASE 50:50 and SASE 25:75. All groups of test animals, except the normal group were given chicken liver juices 1x daily for 14 days, and were given the treatment of test animals from day 7 to day 14. The data obtained were serum uric acid level taken on day 0, day 7 and day 14 and be measured using the method of enzymatic. The data obtained were tested using one-way ANOVA test with 95% confidence level. The combination of water extract bay leaf and ethanol extract celery herb can decrease uric acid level significantly (p < 0,05). Dosages of optimal from a combination of water extract bay leaf and ethanol extract of celery herb to decrease uric acid level that is 50:50 SASE dosage with the average of 14 days average 1,22 mg/dl.

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