UJI EFEK KOMBINASI EKSTRAK AIR DAUN SALAM (Syzigium polyanthum (Wight.) Walp) DAN MENIRAN (Phyllanthus niruri) TERHADAP KADAR ASAM URAT TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI KALIUM OKSONAT

Steffen, Prasetyo (2018) UJI EFEK KOMBINASI EKSTRAK AIR DAUN SALAM (Syzigium polyanthum (Wight.) Walp) DAN MENIRAN (Phyllanthus niruri) TERHADAP KADAR ASAM URAT TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI KALIUM OKSONAT. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Uric acid disease in Indonesia based on Health Research Association (Riskesdas) in 2013 by 11.9% based on health workers and 24.7% based on diagnosis or symptoms Hyperuricemia or better known as increased uric acid levels in the blood is a disease kinetic uric acid disorders . Uric acid is formed when consuming foods that contain lots of purines. Hyperuricemia can also cause a high risk of complications such as gout, urolithiasis, acute uric acid nephropathy. This study aims to find out how big the ability of two combination activities from ethanol extract of bay leaf, and meniran in lowering uric acid levels of male rat induced potassium oxonate? and which comparison is more effective in reducing uric acid levels of male rat induced potassium oxonate? This study used 40 male white rats wistar strain which is divided into 8 groups. Group I as a normal control was given aquadest, group II as a negative control was given CMC-Na 0.5%, group III as positive control was given allopurinol dose 10 mg / KgBB, group IV was given a single dose of 100% salam leaves, group V was given a single dose of herba meniran 100%, groups VI to VIII were given a combination of bay leaf and herbal meniran with a ratio of 75:25; 50:50; 25:75. Prior to rat treatment, hyperuricemia should be made first with potassium oxonate. Salam leaf extract and herbaceous meniran potentially as antihiperurisemia by lowering uric acid levels in male white rats wistar strain induced potassium oxonate (P <0.05). Optimal doses that can reduce uric acid levels are in combination dosage of bay leaf extract and herbal meniran at 75:25 ratio.

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