PERBEDAAN HASIL PEMERIKSAAN KADAR LDLKOLESTEROL DENGAN METODE DIREK (HOMOGENEOUS ASSAY) DAN METODE INDIREK (FORMULA FRIEDEWALD)

Hana, Aristasya (2020) PERBEDAAN HASIL PEMERIKSAAN KADAR LDLKOLESTEROL DENGAN METODE DIREK (HOMOGENEOUS ASSAY) DAN METODE INDIREK (FORMULA FRIEDEWALD). Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Dyslipidemia is a disorder of fat metabolism characterized by high levels of total cholesterol, LDL-cholesterol, triglycerides and a decrease in HDLcholesterol levels. Laboratory tests play an important role in establishing the diagnosis in the management of dyslipidemia. LDL-cholesterol levels become one of the key targets in the treatment of dyslipidemia, measurement of LDLcholesterol levels can be determined using direct and indirect methods. There are various methods of examining LDL-cholesterol, including the direct method (homogeneous assay) and the indirect method (friedewald formula), each method of the examination has advantages and disadvantages. The purpose of this scientific papers is to find out whether there are differences in the results of LDLcholesterol examination using the direct method (homogeneous assay) and the indirect method (friedewald formula). The research method used in scientific papers is the study of literature, that is by collecting data sourced from scientific journals as well as the results of preexisting researchthe results within the last 10 years. Based on the results of literature studies that have been conducted by researchers using descriptive statistics, the results obtained from four scientific sources state that there are significant differences in the results of examining LDL-cholesterol by the direct method (homogeneous assay) and the indirect method (friedewald formula). After analyzing, it can be concluded that there is a significant difference in the examination of LDL-cholesterol levels using the direct method (homogeneous assay) and the indirect method (friedewald formula).

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