POTENSI BAHAN ALAM INDONESIA SEBAGAI ANTIFUNGI ALAMI DALAM MENGHAMBAT PERTUMBUHAN Candida albicans

Yusuf, Nur Iskandar (2020) POTENSI BAHAN ALAM INDONESIA SEBAGAI ANTIFUNGI ALAMI DALAM MENGHAMBAT PERTUMBUHAN Candida albicans. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

In the wild there are many fungi that are pathogenic to humans and animals. One of the pathogenic fungus that can cause disease for humans is Candida albicans. Candida albicans can occurs a candidiasis diseases that can attack mouth, vagina and skin. Efforts to treat candidiasis disease often use synthetic antifungal drugs. However, these synthetic drugs can cause side effects and can even cause pathogenic microbial resistance. Indonesia is a rich country which has so many plants that have potential as traditional medicine. These plants contain active compounds of secondary metabolites that have antifungal characteristic. This study of literature aims to review the potential of Indonesia's natural ingredients as a natural antifungal in inhibiting the growth of Candida albicans and also to know the response of growth inhibition in fungi which is observed from the formation of inhibited zone. This research is based on a literature that use the secondary data taken from scientific journals, theses and scientific writing. Descriptive analysis method used as the technique to arrange the data. Result of the research from seven scientific journals found that gelinggang leaves, mangosteen’s peel, senggani leaves, bee pollen, langsat’s fruit seed, srikaya’s fruit and sembung rambat leaves could inhibit the growth of Candida albicans and also contained secondary metabolite compounds such as alkaloids, flavonoids, terpenoids, steroids, saponins, tannin, squamosin, asymycin, atherospermidine, lanuginosum, annonain, reticulin and glikosides that have antifungal characteristic. Based on the response of growth inhibition in fungi, found some varied results obtained from the antifungal potential of middle to strong antifungal potential. It can be concluded that seven Indonesian’s natural ingredients which identified from this study of literature have sensitivity to Candida albicans with certain concentrations so it’s potentially can be used as natural antifungal and among all identified natural ingredients, senggani leaves with a concentration of 20% were the most effective in inhibiting the growth of Candida albicans

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