UJI AKTIVITAS HEPATOPROTEKTOR JUS BROKOLI (Brassica oleracea L. var. italica) TERHADAP KADAR MALONDIALDEHID HEPAR TIKUS PUTIH GALUR WISTAR YANG DIINDUKSI PARASETAMOL

Fetty, Olivia Dwi (2020) UJI AKTIVITAS HEPATOPROTEKTOR JUS BROKOLI (Brassica oleracea L. var. italica) TERHADAP KADAR MALONDIALDEHID HEPAR TIKUS PUTIH GALUR WISTAR YANG DIINDUKSI PARASETAMOL. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

The use of excessive doses of paracetamol (>2g/days) causes demage to the liver. Paracetamol is generally considered safe by the public but at high doses can cause death. This research was conducted to determine the effect of broccoli juice (Brassica oleracea L. var. italica) in reducing levels of liver MDA in wistarstrain white rats induced by paracetamol. This research was conducted in 6 groups consisting of 5 mouse. Group I as normal control (Aquadest), group II as negative control (CMC-NA 0,5%), group III as a positive control (Silimarin), groups IV to VI were given broccoli juice in a dose of 12.6; 25.2; and 37.8 g / kg for 7 days. On the seventh day after give of broccoli juice, paracetamol was induced at a dose of 2.5 g / kg. After given paracetamol, 48 hours later a liver sample is taken to be carried out by MDA levels. The results showed broccoli juice 12.6; 25.2; and 37.8 g / kg obtained average MDA levels in a row, namely 0.35705; 0.50914; and 0.2329 μM. The provision of broccoli juice has been shown to have hepatoprotector activity in reducing levels of MDA significant way compared to positive group. The dose of broccoli juice 12,6 g/kgBB; 25,2 g/kgBB; dan 37,8 g/kgBB potentially as a hepatoprotector.

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