OPTIMASI FORMULA GEL NANOPARTIKEL EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DENGAN VARIASI KARBOPOL DAN HPMC MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN

Natasha, Intania Pertiwi (2020) OPTIMASI FORMULA GEL NANOPARTIKEL EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DENGAN VARIASI KARBOPOL DAN HPMC MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Green betel (Piper betle L.) contains active compound flavonoid that had antibacterial activity against Staphylococcus aureus which is one of the bacteria that cause acne. Flavonoid had low lipid solubility and poorly absorbed by the skin. Nanoparticles used to increase the penetration of active substances through the stratum corneum. Gel can easily penetrate to the skin that gives healing effect. The aim of this research to made a formulation gel nanoparticles of ethanol extract of betel leaf with an optimal variation of carbopol and HPMC with the Simplex Lattice Design (SLD) method. Betel leaf extraction used maceration method with 70% ethanol solvent. Nanoparticles were made by ionic gelation method with alginate 0,1% and CaCl2 0,02% polymers. Optimal formula is obtained by the SLD method using Design Expert 10 software with parameters pH, viscosity, spreadability, adhesion, antibacterial activity. Verification optimal formula using the One sample t-test, the stability with cycling test method, and acceptability test. The result of optimal formula showed carbopol concentration of 80.9% and HPMC 19.1%. Based the verification, the predictions with the test results were insignificantly different indicated by p values > 0.05 showed method is valid to describe the response as expected. The optimal formula gel has good physical stability and can be accepted by people.

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