PEMBUATAN DAN KARAKTERISASI NANOPARTIKEL EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DENGAN METODE GELASI IONIK

Nisa, Sindi Astuti (2020) PEMBUATAN DAN KARAKTERISASI NANOPARTIKEL EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DENGAN METODE GELASI IONIK. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Nanoparticles are very small material coating technique, with an average diameter of 1-1000 nm. Flavonoid have a low bioavailability the caused by low solubility in water and absorption is limited to the gastrointestinal and intestines. Nanoparticles have been shown to be able to increase the bioavailability of the low solubility drug in the systemic circulation. The aim of this research is preparation and characterization of the betel leaf nanoparticles which include particle size, zeta potential, particle morphology, as well as qualitative analysis of flavonoid content. Preparation of nanoparticles with ionic gelation method using alginic acid polymer of 0.1% and CaCl2 0.02%. Characterization of nanoparticle size using Particle Size Analysis (PSA) indicates the particle size 276,36±56,70 nm. The morphology of nanoparticles with Scanning Electron Microscopy (SEM) indicates the particle is not spherical. The potential zeta value used the Zetasizer23 ± 0.35mV. Qualitative analysis by thin-layer chromatography (TLC) indicates presence flavonoid between the initial extract of the betel leaf and nanoparticles are made of betel leaf extract.

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