UJI AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK ETANOL BROKOLI (Brassica oleracea L. var. italica) DENGAN DAUN ALPUKAT (Persea americana) PADA TIKUS PUTIH YANG DIINDUKSI ALKOHOL DENGAN PARAMETER SGPT

Sri, Suhartini (2020) UJI AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK ETANOL BROKOLI (Brassica oleracea L. var. italica) DENGAN DAUN ALPUKAT (Persea americana) PADA TIKUS PUTIH YANG DIINDUKSI ALKOHOL DENGAN PARAMETER SGPT. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

The liver has many important functions for the body, one of which is to protect the accumulation of harmful and toxic substances that enter from outside the body (xenobiotic substances), motto “back to nature” that often gives significant effects. The purpose of this study was to determine the hepatoprotector activity of a combination of broccoli ethanol extract with avocado leaves as an antioxidant (Hepatoprotective). This research is experimental in 30 male white rats with 6 different treatments namely normal control (aquadest), positive control (silimarin), negative control (alcohol), and treated with a combination of broccoli extract and avocado leaves dose I( 25%:75%), dose II (50%:50%), dose III(75%:25%) that is dose I (750mg/KgBB:375mg/KgBB), dose II (500mg/KgBB:750mg/KgBB), dose III (250mg/KgBB:1125mg/KgBB). The study was conducted for 14 days, on the 15th day blood was drawn through the eye veins to measure SGPT levels and took rat liver for macroscopic observation of the liver. Data were analyzed with the One Way Anova test followed by the Tukey HSD test. This study concluded that the administration of a combination of broccoli ethanol extract with combination of 50%:50% (500mg/KgBB:750mg/KgBB) avocado leaves had the sam hepatoprotector effect as 100 mg/KgBB silimarin.

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