PEMBUATAN DAN KARAKTERISASI NANOPARTIKEL EKSTRAK ETANOL BIJI MELINJO (Gnetum gnemon L.) DENGAN METODE GELASI IONIK

Miftakhul, Sholikhah (2021) PEMBUATAN DAN KARAKTERISASI NANOPARTIKEL EKSTRAK ETANOL BIJI MELINJO (Gnetum gnemon L.) DENGAN METODE GELASI IONIK. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Melinjo seeds (Gnetum gnemon L.) contain flavonoids which have antioxidant and immunomodulatory activities. Flavonoids are easily oxidized and have low bioavailability, so nanoparticles are made to protect and increase their absorption in the body. This research aimed to make and determine the characteristics of melinjo seeds (Gnetum gnemon L.) ethanol extract nanoparticles. The nanoparticles were prepared by ionic gelation method using 0.2% chitosan solution and 0.1% sodium tripolipospate. Characterization includes qualitative analysis of phytochemistry to determine the comparison of the compound content between melinjo seed ethanol extract and melinjo seed ethanol extract in nano preparations, particle size using the Particle Size Analyzer, zeta potential value with Zeta Sizer, and particle morphology using Scanning Electron Microscopy. Nanoparticle colloids are yellow-brown solids. Qualitative analysis of phytochemistry showed the phytochemical content of the extract and nanoparticles of the ethanol extract of melinjo seeds have similarities including essential oils, terpenoids, fats, alkaloids, flavonoids, saponins, and tannins. Characterization using PSA showed the nanoparticle size of 373.40 ± 157.02 nm and the polydispersity index is 0,674±0,382. The zeta potential value is -14.13 ± 2.49 mV. Outcome from using SEM showed that the particle morphology resembles a sphere or lump with an uneven surface and loose structure.

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