FORMULASI SEDIAAN TABLET EKSTRAK DAUN KELENGKENG (Euphoria longana Lam) DENGAN VARIASI POLIVINIL PIROLIDONE (PVP K-30) SEBAGAI PENGIKAT SECARA GRANULASI BASAH

Fatma, Eka Saputri (2021) FORMULASI SEDIAAN TABLET EKSTRAK DAUN KELENGKENG (Euphoria longana Lam) DENGAN VARIASI POLIVINIL PIROLIDONE (PVP K-30) SEBAGAI PENGIKAT SECARA GRANULASI BASAH. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Fever is an increase in body temperature that exceeds normal daily variations and occurs with an increase in the set point temperature in the hypothalamus. Longan leaf (Euphoria longana Lam) is a plant that can be used by the community as an antipyretic or a fever. The phytochemical content contained in longan leaves include saponins, flavonoids, triterpenoids and steroids, tannins, and glycosides. Tablets are chosen in formulations because they have the right dosage for each tablet or per unit of use. This study aims to determine the concentration of PVP K30 can produce tablets from longan leaf extract as a binder that has good physical stability. Longan leaf extract was obtained by extraction with the maceration method using 96% ethanol as a solvent. Tablets were prepared using the ethanol extract of longan leaves with variations in the concentration of PVP K-30 2%, 3%, and 4%. Granule physical stability test includes: Water content test, angle of rest test, flow time test, and tapping test. The results of the granule physical stability test all met the requirements. The physical stability test of tablets was carried out on days 0, 7, 14, 21 including: organoleptic test (shape, color, smell, and taste), weight uniformity test, size uniformity test, hardness test, brittleness test and disintegration time test. The best concentration of PVP K-30 binder as a binder in longan leaf extract tablets (Euphoria longana Lam) is formula I with a concentration of 2% PVP K-30 binder with a weight uniformity test value of (1,611±0,056) size uniformity test of (1,036±0,046) brittleness test (0,545±0,090) hardness test (5,494±0,080) crush time test (10:22±0,055). The higher the level of PVP K-30 increases the hardness, decreases the brittleness and increases the disintegration time of the tablets.

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