FORMULASI TRANSDERMAL PATCH EKSTRAK ETANOL DAUN SALAM (Eugenia polyantha) DENGAN VARIASI KONSENTRASI PVP K-30 DAN ETIL CELLULOSA

Nanda, Arindra (2021) FORMULASI TRANSDERMAL PATCH EKSTRAK ETANOL DAUN SALAM (Eugenia polyantha) DENGAN VARIASI KONSENTRASI PVP K-30 DAN ETIL CELLULOSA. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Flavonoids contained in bay leaves (Eugenia polyantha) are a class of compounds that can lower blood glucose levels. The solubility of flavonoids itself is low in water accompanied by a short filling time in the small intestine so as to provide low absorption and often causes problems for medical applications. Therefore patch preparations were made to increase their bioavailability because patches do not experience a first pass effect in the liver and provide consistent delivery over a long period of time. The extract of bay leaves was made by maceration and patches were made with variations of PVP K-30 and Ethyl Cellulose 1: 2 and 1: 3. Bay leaf extract patch preparations were tested for physical properties including organoleptic, uniformity, pH, drying loss, thickness, homogeneity, folding resistance, aseptability test and stability test for 21 days. The results of the physical properties test for transdermal patch preparations showed that with a concentration of PVP K-30: Ethyl Cellulose 1: 2 bay leaf extract can produce good physical properties on the parameters of oragnoleptic, homogeneity, weight uniformity, pH, drying loss, thickness, folding resistance, and aseptability. The difference in the concentration of PVP K-30 and Ethyl Cellulose, the variation concentration of PVP K-30 and Ethyl Cellulose with a ratio of 1: 2 resulted in good physical properties, namely weight uniformity with an average (0.25 ± 0.0058), folding resistance ( > 300), thickness (0.03 ± 0), drying shrinkage (0%), ph (5 ± 0), and aseptability were obtained mean values (3.8).

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