FORMULASI SEDIAAN PATCH DENGAN VARIASI PEG 400 SEBAGAI PLASTISIZER MENGGUNAKAN EKSTRAK DAUN SELEDRI (Apium graveolens Linn.)

Novita, Puspita Sari (2021) FORMULASI SEDIAAN PATCH DENGAN VARIASI PEG 400 SEBAGAI PLASTISIZER MENGGUNAKAN EKSTRAK DAUN SELEDRI (Apium graveolens Linn.). Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Hypertension is one of the number one comorbid diseases in the COVID 19 virus infection. Some people often use celery leaves as an alternative herbal treatment. The apigenin content in celery can prevent blood vessel constriction and hypertension. The reason it is made in patch preparations is because the nature of the flavonoid compounds in celery leaves has low water solubility and a short filling time in the small intestine so that it will result in a low absorption process. The purpose of making patch preparations is to improve the bioaviability of flavonoids which are expected to deliver the active substance into the body properly and a preparation that meets the requirements of a good patch test can be obtained. The extraction method used is maceration with 96% ethanol solvent. In this study using a concentration of PEG 400 as a plasticizer of 0%, 10%, 20% and 30%. Patch evaluation includes pouring power, drying time, organoleptic, pH, weight uniformity, percentage of elongation, percentage of water content and resistance of patch folding. . The best formula is shown in formula IV with physical test for patch preparations, namely pH 5 ± 0, weight uniformity 0.39 ± 0.0143, thickness 0.01 mm ± 0.006, elongation percentage 6.66% ± 1.15, percentage of water content 7.9% ± 0.30 and folding resistance >700 times ± 0. The higher the plasticizer concentration used, the more moist and elastic is the patch.

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