UJI AKTIVITAS ANTI-INFLAMASI SEDIAAN SALEP EKSTRAK ETANOL BAWANG DAYAK (Eleutherine palmifolia (L.) Merr) PADA TIKUS PUTIH JANTAN

Nur, Chairul Hidayah (2021) UJI AKTIVITAS ANTI-INFLAMASI SEDIAAN SALEP EKSTRAK ETANOL BAWANG DAYAK (Eleutherine palmifolia (L.) Merr) PADA TIKUS PUTIH JANTAN. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Inflammation is a protective response to tissue injury, one of the tissue injuries caused by physical trauma is an incision. The research design used an experimental study by carrying out an anti-inflammatory test on the ethanol extract of Dayak onions made of ointment for the test animals. The antiinflammatory test method is an incision wound on the test animal. The study was conducted to determine the effect of Dayak ethanol extract ointment on wound healing in test animals. The ointment of Dayak’s ethanol extract made was tested for evaluation of the ointment to meet the requirements for semi-solid preparations. The 20 animals tested were divided into 5 groups, namely: negative control, positive control, 4%, 6%, 8% concentration of Dayak onion ethanol extract ointment. The test animals were shaved and given an incision on day 0, then treated and observed in the form of a reduction in the length of the cut on day 1 to 14. Data were collected on days 3, 6, 9, 12 and 14 by comparing the percentage reduction in incisions that occurred. Then the data obtained were tested for normality using the Shapiro-Wilk Test and carried out a one way ANOVA test with (α = 0.05) for the most effective wound healing by giving Dayak ethanol extract ointment with a concentration of 8%.

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