FORMULASI DAN EVALUASI SEDIAAN PATCH BUCAL EKSTRAK BUAH MENTIMUN (Cucumis sativus L.) DENGAN VARIASI KADAR POLIMER CMC-Na DAN KARBOPOL

Vina, Firdia Aulinnikmah (2021) FORMULASI DAN EVALUASI SEDIAAN PATCH BUCAL EKSTRAK BUAH MENTIMUN (Cucumis sativus L.) DENGAN VARIASI KADAR POLIMER CMC-Na DAN KARBOPOL. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Cucumber contains flavonoids, saponins and vitamin C. It is known that vitamin C and flavonoids have an antioxidant effect by breaking the chains of highly reactive free radicals that tend to form new radicals. The advantages of the buccal patch compared to other dosage forms are that it’s use can be stopped only by removing the preparation from the mucosal surface, the drug delivery can be controlled longer, and the absorption capacity of active substances can be modified by adding a plasticizer and permeation enhancer. This study aims to determine the best formula for CMC-Na and Karbopol in buccal patches of cucumber fruit extract which have good physical properties. Extraction of cucumber using maceration method with 96% ethanol solvent and made 3 formulas for buccal patch preparations. The physical properties test of the buccal patch carried out in this study included organoleptic test, weight uniformity test, pH test, folding resistance test, patch thickness test, and developer test. The best research result for the buccal patch formula was formula I with good concentration of CMC-Na and karbopol (1,6 g :1,4 g), FI with an average weight of 0,087  0,004, pH 5 test (1, drying shrinkage), thickness test 0,01 (0,00, FI expansion test result 350%, and folding endurance test 326 (9,8).

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