FORMULASI DAN EVALUASI NANOEMULSI EKSTRAK MENIRAN (Phyllanthus niruri L.)

Aurellia, Lenka Christy (2021) FORMULASI DAN EVALUASI NANOEMULSI EKSTRAK MENIRAN (Phyllanthus niruri L.). Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Meniran (Phyllanthus niruri L.) contains flavonoids which function as immunostimulants. Nanotechnology can improve drug quality by increasing drug bioavailability, increasing physical stability, and increasing absorption by reducing particle size and extending the surface. The purpose of this study was to determine the physical properties and stability of meniran extract nanoemulsion preparation and to determine the ratio of Tween 80 and PEG 400 with good physical properties and stability. The nanoemulsion is made from the oil phases of virgin coconut oil, Tween 80 surfactant and polyethylenglycol cosurfactant. The nanoemulsion formulations were tested for organoleptic, pH, viscosity,% transmittance, freeze thawing, and droplet size in the formula with the highest %transmittance. The results of physical quality and stability test of meniran extract nanoemulsion preparations showed a difference in pH values, namely the higher the PEG 400 concentration in the nanoemulsion formula, the lower the pH of the preparation. Meniran extract nanoemulsion is stable on storage. In the droplet size test, the results obtained meet the droplet size criteria range, namely the range of 20-500 nm. Comparison of the concentrations of tween 80 and PEG 400 in the nanoemulsion preparation of meniran extracts which has good physical properties and stability is formula 4 with a ratio of 20.75 and 10.25.

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