RESISTENSI BAKTERI GRAM NEGATIF TERHADAP ANTIBIOTIK Ceftazidime DARI SAMPEL KULTUR LABORATORIUM BAKTERIOLOGI STIKES NASIONAL

Melinda, Cahyaningrum (2021) RESISTENSI BAKTERI GRAM NEGATIF TERHADAP ANTIBIOTIK Ceftazidime DARI SAMPEL KULTUR LABORATORIUM BAKTERIOLOGI STIKES NASIONAL. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Antibiotics are natural and synthetic compounds that have the effect of suppressing or stopping biochemical processes in the organism, especially in the process of infection by microbes. National STIKES Bacteriology Laboratory there are 8 species of gram-negative bacterial culture samples namely, Serratia marcescens, Salmonella typhosae, Klebsiella oxytoca, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Providencia rettgeri, and Pseudomonas aeruginosa. Ceftazidime-type antibiotics in the production of the enzyme beta lactamase is the main cause of reistension to antibiotics of the beta-lactam group. The purpose of this study was to determine the level of sensivity of Ceftazidime antibiotics to the growth of 8 Gram Negative Bacterial cultures in the National STIKES Laboratory. This research uses descriptive design. This research was conducted at the National STIKES Bacteriology Laboratory and the research was conducted in January-May 2021. The sample of this study was 8 gram-negative bacteria using the antibiotic ceftazidime. The sampling technique used is Proposive Sample. The results of this study showed that the bacteria Serratia marcescens, Salmonella typhosae, Klebsiella oxytoca, Proteus mirabilis, Escherichia coli, Providencia rettgeri, and Pseudomonas aeruginosa, sensitive to Ceftazidime antibiotics with successive results of 28 mm, 30 mm, 25 mm, 31 mm, 44 mm, 25 mm, 28 mm, while Klebsiella pneumonaie bacteria are resistant to Ceftazidime antibiotics due to the slave zone formed by 15 mm. Klebsiella pneumoniae bacteria are resistant to antibiotic Ceftazidme 30 μg while salmonella typhosae, Serratia marcescen, Klebsiella oxytoca, Proteus mirabilis, Providencia rettgeri, Escherichia coli, and Pseudomonas aeuroginosa are still sensitive to Ceftazidime 30 μg antibiotics.

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