EFEK PEMBERIAN SEDUHAN KOPI (Coffea canephora) DAN SEDUHAN COKLAT (Theobroma cacao L) TERHADAP GAMBARAN HISTOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus)

Nika, Oktavianus (2021) EFEK PEMBERIAN SEDUHAN KOPI (Coffea canephora) DAN SEDUHAN COKLAT (Theobroma cacao L) TERHADAP GAMBARAN HISTOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus). Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

The consumption of coffee and chocolate in Indonesia is always increasing. Coffee and chocolate are drinks that are favored by people of all walks of life. Coffee and chocolate have contained caffeine, which has side effects on the kidneys. Kidneys are organs that are easily damaged due to the presence of substance chemicals. The effects of caffeine cause damage to tubular epithelial cells. This research aims to determine the effect of coffee and chocolate steeping on the kidney histology of white rats (Rattus norvegicus). This research used an experimental type of research, using a posttest only control group design research using 7 groups, including group K0 (control), 3 groups of brewing coffee K1 (3mg/200g/day), K2 (6mg/200g/day) and K3 (12mg/200g/day) and 3 groups of chocolate steeping C1(3mg,/200g/day), C2(6mg/200g/day) and C3(12mg/200g/day). The results of the Mann Whitney test for microscopic observations of kidney histology in groups K2, K3, and C3 had Asymp values. sig p= 0.040; 0.011 and 0.013 (0.05). From the results of these studies, it said that steeping coffee and steeping chocolate can cause changes in the histological picture of rats, in the form of degeneration and necrosis.

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