FORMULASI SEDIAAN PATCH TRANSDERMAL EKSTRAK ETANOL DAUN LENGKENG (Dimocarpus longanLour) SEBAGAI ANTIPIRETIK PADA TIKUS PUTIH JANTAN

Esa, Wahyu Riswanti (2021) FORMULASI SEDIAAN PATCH TRANSDERMAL EKSTRAK ETANOL DAUN LENGKENG (Dimocarpus longanLour) SEBAGAI ANTIPIRETIK PADA TIKUS PUTIH JANTAN. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

The ethanol extract of longan leaf which has antipyretic activity is formulated in preparations transdermal patch so that it is easy to use. The purpose of this study was to determine whether the transdermal patch of longan leaf ethanol extract could meet the physical test requirements and could provide antipyretic effect on male white rats induced by the DPT-HB-HIB vaccine. Longan leaf ethanol extract was formulated in the form of a transdermal patch with a concentration of 0.4% and 1.2%. The transdermal patch was subjected to physical tests which included organoleptic tests, weight uniformity tests, folding endurance tests, pH tests, moisture absorption tests, and thickness tests. The transdermal patch that had met the physical test requirements was then tested for its antipyretic effect using male white rats that had been induced by the DPT-HBHIB vaccine. The antipyretic effect was observed for 3 hours consisting of every 15 minutes in the first 2 hours and every 30 minutes in the next 1 hour. The temperature reduction data obtained was calculated for the AUC and processed using statistics One Way ANOVAand followed by posthoc Tukey to find out there were significant differences between treatment groups. The results showed that the transdermal patch of longan leaf ethanol extract met the physical properties test of the transdermal patch and with concentrations of 0.4% and 1.2% could reduce the rectal temperature of male white rats that had been induced by the DPT-HB-HIB vaccine.

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