OPTIMASI CMC Na DAN CARBOPOL DALAM GEL HAND SANITIZER EKSTRAK ETANOL DAUN SRIKAYA (Annona squamosa)SERTA UJI AKTIVITASNYA TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus

Firda, Ary Widyastuti (2021) OPTIMASI CMC Na DAN CARBOPOL DALAM GEL HAND SANITIZER EKSTRAK ETANOL DAUN SRIKAYA (Annona squamosa)SERTA UJI AKTIVITASNYA TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

The preparation of hand sanitizer gel ethanol extract of srikaya leaf (Annona squamosa) has antibacterial activity of Escherichia coli and Staphylococcus aureus because it contains flavonoids. The stability of the physical preparation of hand sanitizer gel is influenced by the combination of the proportion of CMC Na and carbopol as a gelling agent.This research was conducted to find the most optimum composition of CMC Na and carbopol, and to obtain results that were not significantly different from samples with positive controls. Antibacterial activity if it has the ability to inhibit bacteria will form a clear zone around the well. This research was conducted using a laboratory experimental method by extracting srikaya leaves by maceration which was then continued with the manufacture of gel hand sanitizer with variations in the proportion of CMC Na and carbopol optimization was carried out. One of the optimization methods that can be used to obtain the optimum formula is the Simplex Lattice Design. Antibacterial activity tests were carried out on hand sanitizer gel preparations by looking at the inhibitory power based on the size of the clear zone. Test using independent t-test. Based on the test results obtained the best composition is CMC Na 3% and carbopol 2% desirability value 0.536. The data were analyzed statistically using the SPSS 25 program, the significance value was > 0.05. using the dosage formula to obtain the optimum formula based on the test parameters pH, dispersion, adhesion, and viscosity, the test parameters were carried out byone sample t test. Testing of antibacterial activity against Escherichia coliand Staphylococcus aureus had a mean of 15.7 mm and 19.6, respectively. Inhibition data obtained significantly different results between the sample and the positive control.

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