UJI AKTIVITAS SEDIAAN KRIM EKSTRAK ETANOL DAUN KETAPANG (Terminalia catappa L) TERHADAP LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rattus norvegicus)

Iltizham, Baharuddin (2021) UJI AKTIVITAS SEDIAAN KRIM EKSTRAK ETANOL DAUN KETAPANG (Terminalia catappa L) TERHADAP LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rattus norvegicus). Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Ketapang leaves (Terminalia catappa L) contain compounds of tannins, sterols, triterpenoids, saponins and flavonoids which are compounds that can be used to accelerate the healing of cuts. This research is an experimental study using male wistar rats (Rattus norvegicus). This study was conducted by dividing the test animals into 5 groups including a positive control group (Betadine cream), a negative control group (Cream base), a group of 15%, 20%, and 25% ketapang leaf cream extract. The treatment was by giving a cut with a length of 2cm, and a depth of ± 2mm. Each group was smeared with cream of ± 0.5 grams and observed for 14 days. The research data was processed using statistics using the SPSS Version 22 program with the ANOVA method and continued with the T test. The results of this study showed that the preparation of the ethanol extract cream of ketapang leaves had the activity of accelerating wound healing in male wistar rats and formula 3 with a concentration of 25% showed the same activity. good and there was no significant difference with the positive control (Betadine cream).

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