FORMULASI GEL EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum (Wight) Walp) DAN UJI AKTIVITAS ANTIINFLAMASI PADA TIKUS PUTIH JANTAN GALUR WISTAR

Liyona, Genta Endrati (2021) FORMULASI GEL EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum (Wight) Walp) DAN UJI AKTIVITAS ANTIINFLAMASI PADA TIKUS PUTIH JANTAN GALUR WISTAR. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Inflammation is a local reaction mechanism in the tissue to an infection or injury by involving more mediators. Bay leaves (Syzygium polyanthum (Wight) Walp) contains flavonoid compounds using as anti-inflammatory. Topical preparations were chosen because they minimize unwanted side effects. This study aims to determine the ethanol extract can be formulated in the form of a gel, compared anti-inflammatory gel activity and physical stability of the gel. Bay leaves were extracted by merasi method using 70% ethanol as solvent. The ethanolic extract of bay leaves was formulated in gel preparations with concentrations of 1.5%, 2.5%, 4%. The base and the three formulas were tested for accelerated stability for 3 cycles at a temperature of 4˚C and 40˚C, the tests included organoleptic, homogeneity, spreadability, adhesion, pH, viscosity. Anti-inflammatory test by measuring the volume of the rat's paws. The results of the data obtained were analyzed statistically One Way Anova. The results of the anti-inflammatory test of the ethanol extract of the bay leaves showed that the three concentrations had anti-inflammatory properties on the volume of the soles induced by carrageenan. %PI produced for each concentration was 27.96%±3.70 (1.5%), 23.27%±5.62 (2.5%), 20.81%±2.02 (4%). One Way Anova statistical results p > 0.05 where there was no significant difference between Formula 1, 2 and 3. The statistical results of One Way Anova dispersion showed that there was no significant difference between the Basis and the three Formulas (p > 0.05). And the statistical results of One Way Anova stickiness p < 0.05 where there is a significant difference.

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