OPTIMASI CARBOPOL DAN HPMC DALAM SEDIAAN MASKER ANTIOKSIDAN GEL PEEL-OFF EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) DENGAN METODE SIMPLEX LATTICE DESIGN

Rachel, Kenidya Biantoro (2021) OPTIMASI CARBOPOL DAN HPMC DALAM SEDIAAN MASKER ANTIOKSIDAN GEL PEEL-OFF EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) DENGAN METODE SIMPLEX LATTICE DESIGN. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Pandan leaf extract (Pandanus amaryllifolius Roxb.) contains chemicals of alkaloids, flavonoids, saponins, phenolics that are useful as antioxidants. The advantages of peel-off gel are practical, do not need to be rinsed and do not clog pores. The purpose of this study was to find out the comparison of the most optimal combination of carbopol 940 and HPMC gelling agent base in the formula of peeloff gel antioxidant gel pandan leaf extract. The extract is accelerated using 96% ethanol and then phytochemical screening is carried out. Optimization of peel-off gel preparations of 1000ppm pandan leaf extract and carbopol 940 base combination and HPMC specified using Simplex Lattice Design. The response used is pH, scatter power, viscosity, sticking power, and drying time. Verify the optimum formula with one sample T-Test from SPSS. Test antioxidant activity using the ABTS method with Operating Time at 6 minutes and a maximum wavelength of 734.0 nm with a uv-vis spectrophotometer. The yield of the extract was 8,02% and there were flavonoid, phenolic, saponin and alkaloid compounds in phytochemical screening. Optimization of peeloff gel preparations of pandan leaf extract obtained a comparison of Carbopol 940 and HPMC of 0.773grams: 4,227grams with a desirability value of 0.789. pH test score of 5±0.17; scatter power test value of 6,14±0,05; viscosity test value of 91,05±0,54; fixed power test value of 6.24±0.10; and the drying time value of 24,33±3,18. One Sample T-Test results showed no significant difference that meant valid between SLD predictions and trial results. The results of antioxidant testing on peel-off gel pandan leaf extract had an average IC50 value of 7.43±0.08 which is classified as very strong.

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