EFEKTIVITAS GEL NANOKOLAGEN SISIK IKAN NILA (Oreochromis niloticus) TERHADAP PENYEMBUHAN LUKA INSISI TIKUS GALUR WISTAR

Resmaya, Mellinia Arti Adi (2021) EFEKTIVITAS GEL NANOKOLAGEN SISIK IKAN NILA (Oreochromis niloticus) TERHADAP PENYEMBUHAN LUKA INSISI TIKUS GALUR WISTAR. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Fish scale waste can be used as a collagen-producing raw material where collagen plays an important role in wound healing. Collagen has been widely produced from fish scales but not in the form of nanoparticles. This study aims to find out the effectiveness of tilapia fish scale nanocollagen gel (Oreochromis niloticus) at HPMC concentrations of 6%, 7%, 8% against healing of wistar strain rat incision wounds based on wound parameters healed. The collagen extraction method using the extraction of a combination of acetic acid with the enzyme papain is then made into nanoparticle gel and tested for preparation evaluation. The study used 25 wistar strain mice divided into 5 groups namely positive control (Bioplacenton), negative control (Gel base), HPMC concentration formula of 6%, 7%, and 8%. Treatment by gel applied to the wound is then observed until it heals. The results data analyzed with One Way ANOVA continued post hoc tests. The results showed extraction using a combination of acetic acid with the enzyme papain was able to produce collagen solubility as well as the results of the evaluation test of all four gel preparations met the requirements. On the results of the One Way ANOVA test shows the value of significance 0,001 < 0,05 where the entire treatment group has meaningful differences and continued post hoc tests with values p<0,05 positive control of negative controls, formula 1, and formula 3 while p>0,05 positive control of formula 2.

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