FORMULASI PATCH MUKOADHESIF EKSTRAK ETANOL RIMPANG TEMU KUNCI (Boesenbergia pandurata) DENGAN KOMBINASI POLIMER CMC NA DAN KARBOPOL SERTA UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus

Sinta, Wulandari (2020) FORMULASI PATCH MUKOADHESIF EKSTRAK ETANOL RIMPANG TEMU KUNCI (Boesenbergia pandurata) DENGAN KOMBINASI POLIMER CMC NA DAN KARBOPOL SERTA UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Oral abscess is an infection caused by the bacteria Staphylococcus aureus. Temu Kunci rhizome contains cardamonin, which is a flavoloid compound that can inhibit bacterial growth. A mucoadhesive patch is a drug delivery system that is used by placing it between the gums and the inner cheek membrane. This study aims to determine the best formula for CMC Na and Carbopol in the mucoadhesive patch of temu Kunci rhizome extract which has good physical properties and antibacterial activity against Staphylococcus aureus. Extraction of temu Kunci rhizome using maceration method with 96% ethanol solvent and made 5 formulas for mucoadhesive patch preparations. The physical properties test for mucoadhesive patches included weight uniformity, folding endurance, and pH. Antibacterial activity test of patch preparations was carried out by looking at the inhibition zone. The data obtained were processed by statistical Analysis of Variance. The results of this research that the best formula for mucoadhesive patch is formula 1 with good characteristics. The results of the activity test of the mucoadhesive patch preparation of the ethanol extract of temu Kunci rhizome (Boesenbergia pandurata) against Staphylococcus aureus bacteria showed inhibition by increasing the extract to 30mg and 45mg.

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