UJI EFEK ANTIINFLAMASI TOPIKAL SEDIAAN KRIM EKSTRAK ETANOL DAUN SUJI (Dracaena angustifolia Roxb.) TERHADAP MENCIT PUTIH (Mus musculus albinus)

Roisul, Umah Fatmawati (2020) UJI EFEK ANTIINFLAMASI TOPIKAL SEDIAAN KRIM EKSTRAK ETANOL DAUN SUJI (Dracaena angustifolia Roxb.) TERHADAP MENCIT PUTIH (Mus musculus albinus). Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Inflammation is the body's defense response to fight agents that cause cell damage in an organism, characterized by redness in body parts, feeling hot, painful and sore. Suji leaves contain flavonoids, steroids, phenolics, and tannins. Previous research has shown that suji leaves have anti-inflammatory effects, so they are developed in cream dosage forms for practical purposes in use. This study aims to determine the activity of suji leaf ethanol extract cream as a topical anti-inflammation induced by carrageenan, to determine the optimal concentration of suji leaf ethanol extract and the physical properties of suji leaf ethanol extract cream. Was suji leaf extract using the maceration method with 96% ethanol as solvent Suji leaf extract is made in cream dosage form with the respective concentrations of 5%, 10%, 15%. The basis and the three formulas were tested for the physical quality of the cream including organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type and cream pH. The antiinflammatory activity test on 15 mice was divided into 5 groups, namely the control group (-) cream basis, the control group (+) 2.5% hydrocortisone, the 5% concentration group, the 10% concentration group and the 15% concentration group. The results showed that the 5% concentration of suji leaf ethanol extract cream could provide an optimal topical anti-inflammatory effect on carrageenaninduced mice with a% PI of 36.87% and met the requirements of the cream's physical properties test with a viscosity value of 2000 c.Pa.s, a spreadabability of 4,9 cm, adhesion of 8,8 seconds and a pH of 6 and has good cream stability.

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