UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL HERBA SAMBILOTO (Andrographis paniculata (Burm.f.) Nees) DAN DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS DIABETES MELITUS YANG DIINDUKSI ALOKSAN

Ratih, Andriyani (2019) UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL HERBA SAMBILOTO (Andrographis paniculata (Burm.f.) Nees) DAN DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS DIABETES MELITUS YANG DIINDUKSI ALOKSAN. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Diabetes melitus (DM) is a disease characterized by hyperglycemia caused by decreased insulin secretion or decreased insulin sensitivity or both. The prevalence of diabetes melitus increase every year. The study was conducted to determine the combination of extracts ethanol herbs sambiloto and sambung nyawa leavesbitter a more effective decrease of blood glucose levels in male rat wistar strain induced alloxan as compared to the provision of a single.This research uses experimental research with pre and post test randomized controlled group design. Forty test animals were divided into 8 groups : normal, negative (CMC-Na), positive (glibenclamide),herbs sambiloto (EESA 100), sambung nyawa leaves (EESN 100), EESA : EESN 75:25, EESA : EESN 50:50 and EESA : EESN 25:75. All groups except the normal group induced alloxan 160mg / kgBB on day 0, followed by animal testing until day 14. The data obtained were blood glucose on day 0, day 7 and day 14 and measured using GOD-PAP method. The data obtained by normality test using Shapiro-Wilk test followed by ANOVA test with (α=0.05) for optimum dose combination of ethanol extract herbs sambiloto and sambung nyawa leavesthat is EESA : EESN 50:50 can decrease blood glucose level is 10.25 mg/kgBB herbs sambiloto 70 mg/kgBB sambung nyawa leaves.

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