FORMULASI CAMPURAN GELATIN DAN TEPUNG AGAR SEBAGAI BAHAN PENGIKAT PADA TABLET EKSTRAK DAUN SUKUN (Artocarpus altilis) SECARA GRANULASI BASAH

Yulia, Sendy Natasha (2020) FORMULASI CAMPURAN GELATIN DAN TEPUNG AGAR SEBAGAI BAHAN PENGIKAT PADA TABLET EKSTRAK DAUN SUKUN (Artocarpus altilis) SECARA GRANULASI BASAH. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Breadfruit leaves are one type of medicinal plant that contains flavonoids which are believed to be used for the treatment of the liver. Tablets have the advantage of being easy to consume and precisely measuring, so this study is to determine the effect of a combination of gelatin and agar flour which can produce breadfruit leaf tablets (Artocarpus altilis) with good physical quality and to determine the effect of gelatin and agar flour as a binder in the physical stability test of breadfruit leaf extract tablets (Artocarpus altilis). The reason for using the gelatin binder is that gelatin is used to give compactness to tablets, while agar flour is in order to increase the binding capacity of the tablets. Breadfruit leaf extract tablet made by wet granulation method because the active ingredient of breadfruit leaf (Artocarpus altilis) is not resistant to heating above 50oC. Formula of breadfruit leaf extract tablet (Artocarpus altilis) with gelatin binding agent that is 4%, 6%, 8%, 10% and agar flour that is 0.5%, 1%, 1.5%, 2.0%, it is expected to be able to produce tablets that meet the requirements of tablet weight uniformity test, tablet hardness test, tablet fragility test, and tablet disintegration time test for 28 days. The concentration of gelatin and agar flour binder to give effect to the physical properties of granules and physical properties of tablets, the concentration of gelatin and agar flour binder that is good is formula IV with a concentration of 4% gelatin and 2% agar flour, with an average weight uniformity test result of 0.515 ± 0.005 g, an average tablet hardness test result of 1.15 ± 0.029 kg, the average tablet fragility test results were 2.934 ± 0.631%, the average results of the tablet disintegration test were 5.07 ± 0.11 minutes.

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