OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN

Ita, Mustika Putri Setyadi (2021) OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN. Diploma thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Blue Pea (Clitoria ternatea L.) contains flavonoid compounds which have pharmacological effects, which is one of anti-inflammatory. In previous studies, flower telang (Clitoria ternatea L.) was shown to have anti-inflammatory effects. Transdermal patch is a form of drug delivery system that is attached through the skin. This study aims to obtain the optimum combination of HPMC and Na CMC formulas as polymers in the transdermal formula patch of the ethanol extract of telang flower (Clitoria ternatea L.). Transdermal patch combination of HPMC and Na CMC was made with Software Design Expert version 11 of the method Simplex Lattice Design and acceptability test. The evaluation of the transdermal test for patch the ethanol extract of the telang flower includes pH test, weight test, thickness test, folding test and moisture content test, which is then verified by the SPSS program using the method one sample t-test. The concentration of the optimum formula for the combination of HPMC : Na CMC as a polymer with transdermal preparations patch is in the ratio (3.5%: 1%) and has a desirability value of 0.944,to verify the optimal formula for transdermal patches valid results are obtained. The results of the acceptability test concluded that the respondents were well accepted by the respondents.

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