PERBANDINGAN DAYA HAMBAT EKSTRAK ETANOL 70% DAN ETANOL 96% BIJI PEPAYA (Carica papaya L) TERHADAP PERTUMBUHAN Escherichia coli ESBL

Laurencia, Destivani Virliana Widjayanti (2021) PERBANDINGAN DAYA HAMBAT EKSTRAK ETANOL 70% DAN ETANOL 96% BIJI PEPAYA (Carica papaya L) TERHADAP PERTUMBUHAN Escherichia coli ESBL. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Extended-Spectrum Beta Lactamase (ESBL) is an enzyme that produced by gram negative bacteria which is Escherichia coli. This type of bacteria is able to produce beta lactamase enzymes that can fight beta lactam antibiotics, for example cefotaxime and ceftriaxone. The prevalence of infection by ESBL producing bacteria is 50,60%. Due to the increasing number of infections by ESBL producing bacteria that become challenges to find natural ingridients that can be new alternatives to overcome these problems. Carica papaya L seeds are one of the natural ingredients that can be used. This study used an analytic experimental type of research by conducting antibacterial activity tests to determine the comparoson of the inhibitory power of 70% ethanol and 96% ethanol extract of papaya seeds (Carica papaya L) on the growth of Escherichia coli ESBL. This study used Carica papaya L seeds for the sample taken from the ripe and fresh papaya and then dried it. The Carica papaya L seeds extracted use percolation method and used 70% ethanol and 96% ethanol as the solvent then made dilution in 100.000 ppm, 200.000 ppm, 300.000 ppm, 400.000 ppm, dan 500.000 ppm. The antibacterial activity using disk diffusion method with MHA media. In this study, the results obtained by the Kruskal Wallis test with a sig value is <0,001 and it can be concluded that there is a significant difference in the inhibition of 70% ethanol and 96% ethanol extract of papaya seeds (Carica papaya L) on the growth of Escherichia coli ESBL.

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