OPTIMASI FORMULA PATCH DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI PEPAYA (Carica papaya L.) DENGAN KOMBINASI MATRIKS HPMC DAN PEG 400 TERHADAP Staphylococcus aureus

Tristina, Yulianti (2021) OPTIMASI FORMULA PATCH DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI PEPAYA (Carica papaya L.) DENGAN KOMBINASI MATRIKS HPMC DAN PEG 400 TERHADAP Staphylococcus aureus. Other thesis, Sekolah Tinggi Ilmu Kesehatan Nasional.

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Abstract

Acne is a skin disease caused by inflammation accompanied by blockage of skin and hair oil (pilosebaceous tract) which is characterized by the presence of comedo, papules, pustule, and nodule. One of the bacteria that cause acne is Staphylococcus aureus. Papaya seeds (Carica papaya L.) contain flavonoid compounds, alkaloid and terpenoid which have been known to have antibacterial activity. Patch are preparations with an adhesive (adhesive layer) containing a drug, which is placed on the skin to deliver a certain dose of medication through the skin. The purpose of this study was to determine the combination of HPMC and PEG 400 which can provide a good antibacterial effect and to determine the evaluation of a good physical patch preparation. Extraction of papaya seeds using maceration method with 96% ethanol solvent, and made 8 patch formulation. The physical properties of the patch preparation included weight uniformity, folding endurance, thickness, and pH. The antibacterial activity test of the patch preparation was carried out using the Kirby Bauer method. The data obtained were processed by statistical Analysis of Variance (ANOVA). The result of the research that the patch formula with a combination of HPMC 5,09 gram and PEG 4,91 gram had good characteristic. The result of the activity test for the etanol extract of papaya seeds (Carica papaya L.) against Staphylococcus aureus showed an average inhibition of 17,59 mm with a strong category.

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